![]() Pretreatment: Limited data available: Note: Recommended for use when high-dose metoclopramide is required and should be considered when use of other medications known to have a high risk of EPS (eg, high-dose chlorpromazine or prochlorperazine) are required ( Ref). Subsequent doses (if needed): IV, Oral: 5 mg/kg/day in equally divided doses administered every 6 to 8 hours for up to 2 to 5 days may be considered to prevent recurrence. Oral therapy may be considered for home use while medical care is sought ( Ref). ![]() Initial: IV (preferred), IM, Oral: 1 to 2 mg/kg/dose maximum dose: 50 mg/dose may repeat in 30 minutes if no response. Infants ≥9 kg and Children: Oral: 5 mg/kg/day in equally divided doses administered every 6 to 8 hours as needed usual age-related single doses: <6 years: 6.25 mg/dose 6 to 11 years: 25 mg/dose ≥12 years: 25 to 50 mg/dose maximum dose: 50 mg/dose ( Ref).Īdolescents: Oral: 5 mg/kg/day in equally divided doses administered every 6 to 8 hours as needed usual dose: 25 to 50 mg/dose maximum dose: 50 mg/dose.Įxtrapyramidal symptoms (EPS) (eg, medication-induced dystonic reactions): Dosing recommendations are based on general dosing range in the manufacturer's labeling. For atopic dermatitis, diphenhydramine may provide intermittent relief of pruritus and may help with sleep loss associated with the pruritus however, it does not treat underlying condition and is not a substitute for topical therapy chronic use is not recommended ( Ref). Note: First-generation antihistamines (eg, diphenhydramine) are not recommended as first-line agents for urticaria (acute or chronic) due to risk of adverse reactions second-generation antihistamines are preferred ( Ref). Infants ≥9 kg, Children, and Adolescents: Oral: 5 mg/kg/day in equally divided doses every 6 to 8 hours age-related maximum single doses: <6 years: 6.25 mg/dose 6 to 11 years: 25 mg/dose ≥12 years: 50 mg/dose ( Ref).Ĭutaneous disorders with pruritus (eg, urticaria, atopic dermatitis, other pruritic skin conditions): Infants and neonates are highly sensitive to depressive effects of diphenhydramine use is contraindicated in neonates (premature and term) use with extreme caution in infants and young children.įixed dosing: Note: Although manufacturer labeling allows for every-4-hours dosing, the pharmacokinetics in pediatric patients suggest that a longer dosing interval is adequate reassess patient's symptoms prior to each dose.Ĭhildren 2 to <6 years: Limited data available: Oral: 6.25 mg every 4 to 8 hours as needed ( Ref).Ĭhildren ≥6 to <12 years: Oral: 12.5 to 25 mg every 4 to 8 hours as needed ( Ref).Ĭhildren ≥12 years and Adolescents: Oral: 25 to 50 mg every 4 to 8 hours as needed ( Ref). Note: Due to adverse effects (paradoxical agitation/excitation or sedation), first-generation H 1 antihistamines (eg, diphenhydramine) are not recommended as first-line therapy for management of allergic rhinitis in pediatric patients second-generation minimally sedating antihistamines are preferred ( Ref). Allergic rhinitis/rhinoconjunctivitis (including upper respiratory allergies or hay fever):
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